FDA approves non-chemotherapy drug regimen for acute myeloid leukemia

Don A. Stevens, M.D., an oncologist at Norton Cancer Institute, was a pivotal investigator in this treatment’s clinical trial, enrolling Louisville-area patients living with acute myeloid leukemia (AML).

The Food and Drug Administration (FDA) recently approved Venclexta (venetoclax) as part of a non-chemotherapy treatment of newly diagnosed acute myeloid leukemia (AML) in adults 75 years or older, or who have comorbidities that preclude use of intensive induction chemotherapy.

Don A. Stevens, M.D., an oncologist at Norton Cancer Institute, was a pivotal investigator in this treatment’s clinical trial, enrolling Louisville-area patients living with AML.

The trial examined using Venclexta in combination with azacitidine, or decitabine, or low-dose cytarabine (LDAC). The full approval for this use of Venclexta follows the FDA’s November 2018 grant of provisional approval.

The approval is based primarily on the results of two Phase 3 studies, including one published in the New England Journal of Medicine in August 2020. The studies showed Venclexta plus azacitidine significantly reduced the risk of death by 34% compared with azacitidine alone.

Refer a patient

Use Norton EpicLink to quickly and easily refer a patient to Norton Cancer Institute.

Make a referral


Get Our Monthly Newsletter

Stay informed on the latest offerings and treatments available at Norton Healthcare by subscribing to our monthly enewsletter.

Subscribe

Make a Referral

Partnering with you in caring for your patients.

Refer a Patient
Are You a Patient?
Provider Spotlight

Meagan Molestina, APRN

Meagan Molestina, APRN, cares for kids at Norton Children’s Nephrology.

Read More

Search our entire site.