Research Archives - Norton Healthcare Provider

Gilteritinib and venetoclax regimen yields encouraging results against FLT3-mutated AML

A new regimen of FMS-related tyrosine kinase 3 (FLT3) inhibitor gilteritinib and venetoclax was tolerable at standard doses and produced high response rates for advanced, FLT3-mutated acute myeloid leukemia (AML) in a multicenter Phase 1 [...]

Mental health and provider considerations when treating multiple sclerosis

As mental health disorders can be one of the “invisible” symptoms of multiple sclerosis (MS), mental health care can be a part of routine MS care through the regular use of screening tools and an [...]

Essentials of clinical trials

Clinical trials and studies, which are essential to the development of new drugs and treatments, need to be conducted under strict ethical, clinical and investigational structures. The most common are investigational trials with new medications [...]

Clinical research: Asking questions, sharing answers

Clinical research drives progress for every element of health and requires global collaboration. At Norton Healthcare alone, our research teams lead and contribute to studies about pediatric medicine, cancer, infectious diseases, cardiology, neurology, the spine, […]

Advancing the standard of cancer care and offering patients access to new therapies

Our goal is to offer every patient the option of the latest treatment available for their cancer. To do that, Norton Cancer Institute is participating in approximately 170 clinical trials at any time. These clinical [...]

First successful “valve-in-MAC” transcatheter mitral valve replacement in Louisville region

A multidisciplinary team of interventional cardiologists and a cardiothoracic surgeon performed Louisville’s first successful transcatheter replacement of a native mitral valve this week. The team with Norton Heart & Vascular Institute Structural Heart Program used […]

Clinical trial summary: Venetoclax plus LDAC for adult AML patients at high risk of toxicity

Clinical challenge Acute myeloid leukemia (AML) patients ages 75 and older, and younger adults with comorbidities, are often ineligible to receive standard intensive chemotherapy due to high rates of toxicity and early mortality. As a [...]

Study looks at how to detect RSV in adults

Norton Infectious Diseases Institute has been selected by Pfizer as the only site in United States to study how to effectively detect respiratory syncytial virus (RSV) in adults. “For the most part, RSV attention has [...]

New guidelines for bone health assessment before elective spinal reconstruction

The Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for Perioperative Spine: Preoperative Osteoporosis Assessment recently was published in Neurosurgery. To develop these recommendations, the authors performed systematic review of the literature using national [...]

New evidence-based guidelines published for perioperative spine surgery assessments

New evidence-based guidelines covering five key perioperative spine assessments were issued recently by the Congress of Neurological Surgeons. The guidelines, published in the medical journal Neurosurgery, provide insight on the following: Preoperative osteoporosis assessment Preoperative […]

Drug targeting prostate cancer cells to deliver radioisotope prolongs survival in trial

A cutting-edge new treatment specifically targets prostate cancer cells to deliver a tumor-killing radioisotope and helped extend patients’ lives longer in an international clinical trial (VISION Study), according to a study published in the New […]

Access to evolving clinical science close to home

Norton Cancer Institute’s clinical research program was developed to ensure that cancer patients in our community and region have access to evolving clinical science. Guided by an experienced cadre of physicians and supported by a […]

Category: Research