Norton Heart & Vascular Institute has joined a select group of North American centers in a landmark randomized clinical trial aimed at reducing one of cardiac surgery’s most common and consequential complications: postoperative atrial fibrillation (POAF). About the trial Postoperative atrial fibrillation affects more than half of patients undergoing cardiac surgery, depending on individual risk…
Norton Heart & Vascular Institute continues to expand its role in advancing cardiovascular clinical research, joining a global clinical trial that potentially could redefine treatment for one of heart failure’s most challenging patient populations: heart failure with preserved ejection fraction, or HFpEF. Why it matters HFpEF patients retain normal left ventricular pumping function (LVEF ≥50%)…
What your patients eat may shape who they become A landmark study published in JAMA Network Open is giving pediatric providers new clinical ammunition for conversations about early childhood nutrition — and the findings go well beyond waistlines. Studies on the link between processed food and behavior have been around for a while and evaluate…
Reviewed by Bassel Alkhalil, M.D., Norton Heart & Vascular Institute Norton Heart & Vascular Institute has been selected as one of only two sites in Kentucky to participate in TEAM-HF, a pioneering clinical trial that could fundamentally change how advanced heart failure is treated. The study, sponsored by Abbott and led locally by principal investigator…
Norton Cancer Institute has added significant clinical oncology research expertise with the arrival of Kevin T. Breen, M.D., Ph.D., who is expected to become one of the new leaders of Norton Cancer Institute’s early-phase clinical trials program. Dr. Breen brings specialized knowledge in brain cancer immunotherapy from his previous work at the National Institutes of…
A groundbreaking clinical trial at Norton Cancer Institute is exploring whether CAR T-cell therapy —a cellular therapy originally developed to treat cancer — could provide a curative treatment for patients with severe autoimmune diseases, including systemic lupus erythematosus (SLE), myositis and scleroderma. The RESOLUTION trial, led by principal investigator Don A. Stevens, M.D., hematologist/oncologist with…
Reviewed by Anupama Raghuram, M.D., and Julio A. Ramirez, M.D. Norton Infectious Diseases Institute researchers are challenging the traditional view of pneumonia as a self- limited acute lung infection, revealing that the disease may be associated with chronic complications affecting multiple organ systems for years after initial diagnosis. Julio A. Ramirez, M.D., and Anupama Raghuram,…
Norton Cancer Institute’s gynecologic oncology research program continues to expand rapidly, helping address a critical regional gap in specialty treatment and clinical research access. Nationally, gynecologic oncology is heavily driven by early phase trials, underscoring the need for programs that advance novel therapies and accelerate progress in treatment options. Our current gynecologic oncology studies include…
Norton Healthcare and Norton Children’s are now contributing vital resources to diabetes research efforts nationwide. As a new member of the Integrated Islet Distribution Program (IIDP), the Norton Islet Cell Research and Transplant Program, housed within Wendy Novak Diabetes Institute, supplied its first round of human pancreatic islet cells to researchers across the country, including…
[vc_row][vc_column][vc_column_text]Norton Children’s Pulmonology, affiliated with the UofL School of Medicine, is actively recruiting adolescent participants who meet criteria for a clinical trial of two inhaled treatments for asthma. According to the Centers for Disease Control and Prevention, more than 6 million children in the United States have asthma. Even with sufficient symptom management, asthma exacerbations…
Failure of endoscopic third ventriculostomy (ETV) to relieve hydrocephalus in patients with midline brain tumors may be an early indication of an underlying histone H3K27M mutation, according to a recently published study.
[vc_row][vc_column][vc_column_text]Cardiac centers around the world are accepting patients for a clinical trial for patients undergoing cardiac surgery that may have risk factors for atrial fibrillation (A-fib) and ischemic stroke.