Patients 18 years of age and older with cystic fibrosis now have an option of participating in a Phase 1 trial of a novel, broad-spectrum, orally delivered enzyme replacement therapy for cystic fibrosis (CF). The randomized, active-treatment trial is testing the safety, tolerability and effect of four dose levels of ANG003, a compound developed by…
The patient A 64-year-old woman tripped after “missing a step,” fracturing her left tibial plateau and resulting in deformity of the joint. This was managed conservatively, with a leg brace removing weight from the extremity. She developed persistent numbness and tingling in her left leg, as well as weakness. She was evaluated in the Norton…
Paul A. Kniery, M.D. Internal Medicine Stephen Love, M.D. Behavioral Medicine Sarah A. Mayfield, M.D. Internal Medicine Emmanuel A. Nidhiry, M.D. Medical Oncology and Hematology Anupama Raghuram, M.D. Infectious Diseases Elizabeth Fahey, PA-C Hand Surgery Kathryn Hardesty, PA-C General Surgery Kyla M. Byard, APRN Family Medicine Stacie S. Cheney, APRN Family Medicine Anna N. Ertel,…
In 2023, the Food and Drug Administration (FDA) approved lecanemab (brand name Leqembi) for the treatment of Alzheimer’s disease. Lecanemab is the first widely used medication in a new class of anti-amyloid agents for the treatment of patients with mild cognitive impairment (MCI) or early stages of Alzheimer’s disease. This is the first new Alzheimer’s…
Not-for-profit Norton Healthcare and Norton Children’s ask for the community’s help to improve health and quality of life for every person in Kentucky and Southern Indiana. The organization, along with local and community leaders, announced its “Just Imagine” campaign, which aims to raise $200 million in the next two years to support investments in health care…
Norton Arm & Hand Institute is the new name for Norton Louisville Arm & Hand, as of March 1, 2024. The goal of Norton Arm & Hand Institute is to be a destination program by establishing itself as a thought and practice leader in upper extremity care. The institute is founded upon five pillars: clinical…
The Norton Healthcare Antimicrobial Stewardship Program was recognized this year as the first and only antimicrobial stewardship center of excellence in the United States by the British Society of Antimicrobial Chemotherapy. The international collaboration is part of the society’s new Global Antimicrobial Stewardship Accreditation Scheme. The accreditation process, developed by BSAC and led by experts…
Norton Cancer Institute is enrolling metastatic lung cancer patients in a Phase 3 clinical trial to test a promising new anti-CLTA-4 antibody, gotistobart (ONC-392). The study will test whether gotistobart is more effective than the chemotherapy agent docetaxel in prolonging life in patients with metastatic, non-small cell lung cancer whose disease progressed on anti-PD-1/PD-L1 antibody…
Scott M. McClain, M.D. Emergency Medicine Stephen R. Roszell, M.D. Urgent Care Jerome J. Tuitt, M.D. Hospital Medicine Shengnan Zheng, M.D. Hospital Medicine Timothy J. Ziolkowski, M.D. Emergency Medicine Katharine Adelstein, APRN Psycho-oncology Lunden A. Barnes, APRN Urgent Care Rachel F. Bass, APRN Family Medicine Taylor D. Burkhardt, APRN Urgent Care Megan A. Cramer, APRN…
What are “exercise snacks”? A newer concept for evidence-based exercises, called “exercise snacks” or “activity snacks,” is gaining traction for helping improve health outcomes for patients with sedentary lifestyles. These “snacks,” which involve short bursts of exercises implemented throughout the day, can offer many health benefits without significantly disrupting a patient’s existing daily routines. Studies…
Patients who have been pregnant and especially those who had complicated pregnancies are at higher risk for cardiovascular disease, but the condition typically arises 10 or 15 years after the pregnancy. Patients are screened months after their pregnancy for cardiovascular disease, but as the patient ages, pregnancy is a very important part of their medical…
The patient A 67-year-old woman with a past medical history of chronic obstructive pulmonary disease and emphysema presented with a spiculated right upper-lobe nodule that was previously 8 millimeters in size on CT scan of the lung. In six months, it had increased in size to 1.1 centimeters. The challenge The lung nodule was small,…