Research

Study shows low-dose cadmium threshold for testicular ferroptosis in mice

Cadmium, a natural element used for rechargeable batteries and other industrial applications, can induce a novel type of testicular cell death in mice after low-dose exposure, according to a groundbreaking study. Cadmium is known to […]

First successful “valve-in-MAC” transcatheter mitral valve replacement in Louisville region

A multidisciplinary team of interventional cardiologists and a cardiothoracic surgeon performed Louisville’s first successful transcatheter replacement of a native mitral valve this week. The team with Norton Heart & Vascular Institute Structural Heart Program used […]

Clinical trial summary: Venetoclax plus LDAC for adult AML patients at high risk of toxicity

Clinical challenge Acute myeloid leukemia (AML) patients ages 75 and older, and younger adults with comorbidities, are often ineligible to receive standard intensive chemotherapy due to high rates of toxicity and early mortality. As a [...]

Drs. Ramirez and Carrico

Study looks at how to detect RSV in adults

Norton Infectious Diseases Institute has been selected by Pfizer as the only site in United States to study how to effectively detect respiratory syncytial virus (RSV) in adults. “For the most part, RSV attention has [...]

Michael L. Sweeney, M.D., co-authored a review of anti-CD20 monoclonal antibody therapy.

Anti-CD20 monoclonal antibody therapy for relapsing MS in adult patients

Anti-CD20 monoclonal antibody therapy represents a major advance in treating relapsing multiple sclerosis (MS) in adult patients, reducing relapse risk and mitigating disability progression. These monoclonal antibody therapies deplete circulating B cells by targeting CD20, [...]

Reduced-toxicity myeloablative conditioning regimen effective against high-risk pediatric leukemias

A low-toxicity myeloablative conditioning regimen is safe and effective in treating high-risk leukemias, particularly myeloid disease, according to a study recently published in the journal Pediatric Blood & Cancer. Conventional myeloablative conditioning is effective at […]

New guidelines for bone health assessment before elective spinal reconstruction

The Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for Perioperative Spine: Preoperative Osteoporosis Assessment recently was published in Neurosurgery. To develop these recommendations, the authors performed systematic review of the literature using national [...]

As mental health disorders can be one of the “invisible” symptoms of multiple sclerosis (MS), mental health care can be a part of routine MS care through the regular use of screening tools and an integrated approach to treatment.

Mental health and provider considerations when treating multiple sclerosis

As mental health disorders can be one of the “invisible” symptoms of multiple sclerosis (MS), mental health care can be a part of routine MS care through the regular use of screening tools and an [...]

New evidence-based guidelines published for perioperative spine surgery assessments

New evidence-based guidelines covering five key perioperative spine assessments were issued recently by the Congress of Neurological Surgeons. The guidelines, published in the medical journal Neurosurgery, provide insight on the following: Preoperative osteoporosis assessment Preoperative […]

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Provider Spotlight

Amy Farrell, M.D.

Amy E. Farrell, M.D., is where she wants to be, practicing medicine in her hometown of Bardstown, Kentucky.

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Talking about weight with patients

Obesity affects approximately 70 million Americans. Kentucky consistently ranks in the top 10 states for obesity. According to Kentucky Health Facts, 32% of adults in Jefferson County are classified as obese. Yet physicians may be […]

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Schroth method provides nonsurgical treatment for scoliosis

Norton Leatherman Spine offers a scoliosis exercise program based on the methods first used by German scoliosis patient Katharina Schroth. The method’s namesake had moderate scoliosis herself, and after years of wearing uncomfortable steel braces, […]

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Limping child red flags: What not to overlook as signs of serious conditions

When a child who plays sports is limping, it’s often the result of a sprain or an overuse injury, but there are more serious injuries and conditions a clinician should consider. “In many cases there […]

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Cancer care disparities in Kentucky

Kentucky leads the nation in cases of lung cancer. Cancer patients in our region also experience barriers to care and racial disparities in care. In a recent presentation on pursuing health equity in lung cancer […]

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How providers play a role in reducing maternal mortality rates and racial disproportionality

Black people are nearly 3 times more likely to die of pregnancy-related complications than white people, and the alarming rate of maternal mortality and the racial gap in pregnancy loss and pregnancy-related deaths are nationwide […]

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