Research

First successful “valve-in-MAC” transcatheter mitral valve replacement in Louisville region

A multidisciplinary team of interventional cardiologists and a cardiothoracic surgeon performed Louisville’s first successful transcatheter replacement of a native mitral valve this week. The team with Norton Heart & Vascular Institute Structural Heart Program used […]

Clinical trial summary: Venetoclax plus LDAC for adult AML patients at high risk of toxicity

Clinical challenge Acute myeloid leukemia (AML) patients ages 75 and older, and younger adults with comorbidities, are often ineligible to receive standard intensive chemotherapy due to high rates of toxicity and early mortality. As a [...]

Drs. Ramirez and Carrico

Study looks at how to detect RSV in adults

Norton Infectious Diseases Institute has been selected by Pfizer as the only site in United States to study how to effectively detect respiratory syncytial virus (RSV) in adults. “For the most part, RSV attention has [...]

Michael L. Sweeney, M.D., co-authored a review of anti-CD20 monoclonal antibody therapy.

Anti-CD20 monoclonal antibody therapy for relapsing MS in adult patients

Anti-CD20 monoclonal antibody therapy represents a major advance in treating relapsing multiple sclerosis (MS) in adult patients, reducing relapse risk and mitigating disability progression. These monoclonal antibody therapies deplete circulating B cells by targeting CD20, [...]

Reduced-toxicity myeloablative conditioning regimen effective against high-risk pediatric leukemias

A low-toxicity myeloablative conditioning regimen is safe and effective in treating high-risk leukemias, particularly myeloid disease, according to a study recently published in the journal Pediatric Blood & Cancer. Conventional myeloablative conditioning is effective at […]

New guidelines for bone health assessment before elective spinal reconstruction

The Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for Perioperative Spine: Preoperative Osteoporosis Assessment recently was published in Neurosurgery. To develop these recommendations, the authors performed systematic review of the literature using national [...]

As mental health disorders can be one of the “invisible” symptoms of multiple sclerosis (MS), mental health care can be a part of routine MS care through the regular use of screening tools and an integrated approach to treatment.

Mental health and provider considerations when treating multiple sclerosis

As mental health disorders can be one of the “invisible” symptoms of multiple sclerosis (MS), mental health care can be a part of routine MS care through the regular use of screening tools and an [...]

New evidence-based guidelines published for perioperative spine surgery assessments

New evidence-based guidelines covering five key perioperative spine assessments were issued recently by the Congress of Neurological Surgeons. The guidelines, published in the medical journal Neurosurgery, provide insight on the following: Preoperative osteoporosis assessment Preoperative […]

Drug targeting prostate cancer cells to deliver radioisotope prolongs survival in trial

A cutting-edge new treatment specifically targets prostate cancer cells to deliver a tumor-killing radioisotope and helped extend patients’ lives longer in an international clinical trial (VISION Study), according to a study published in the New […]

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Provider Spotlight

Ayryn Page Chilton-Gelfo, PA-C

Ayryn P. Chilton-Gelfo, PA-C, has joined Norton Heart & Vascular Institute.

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Case study: Awake brain tumor resection helps preserve healthy tissue

The patient A 39-year-old nursing student initially presented with complaints of a two-year history of intermittent numbness in the tips of the middle and ring finger on her left hand. Over the past six months, […]

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Case Study: Uncovering a hidden case of pediatric septic arthritis

The patient A 14-month-old female presented to the emergency department with fever and refusal to bear weight. She had bilateral ear tube insertion 13 days previously and presented to her primary care provider (PCP) three […]

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Ayryn P. Chilton-Gelfo, PA-C, joins Norton Heart & Vascular Institute

Ayryn P. Chilton-Gelfo, PA-C, has joined Norton Heart & Vascular Institute. The physician assistant is seeing patients in offices in downtown Louisville, on the Norton Audubon Hospital, Norton Brownsboro Hospital and Norton Healthcare – St. […]

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Norton Women’s Doula Program works to improve health outcomes for Black mothers

Norton Women’s Doula Program currently has three doulas who are actively working with patients, with plans for additional doulas to join the expanding program soon. “Our doula program is the first of its kind in […]

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Headache or migraine: How to spot the red flags

Not all headache or migraine symptoms in children signify red flags that require additional referrals or advanced treatment, said Elizabeth S. Doll, M.D., child neurologist at Norton Children’s Neuroscience Institute, affiliated with the UofL School […]

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