Researchers at the Norton Healthcare Brain Tumor Center are conducting a clinical trial to determine whether a promising new immunotherapy drug, SurVaxM, improves survivability of glioblastoma. SurVaxM targets survivin, a protein in 95% of glioblastomas and many other cancers. The immunotherapeutic is designed to trigger the patient’s immune system to attack cancer cells with survivin….
A new regimen of FMS-related tyrosine kinase 3 (FLT3) inhibitor gilteritinib and venetoclax was tolerable at standard doses and produced high response rates for advanced, FLT3-mutated acute myeloid leukemia (AML) in a multicenter Phase 1 study. “The results were encouraging. We saw high rates of marrow response and promising overall survival for this high-risk group…
As mental health disorders can be one of the “invisible” symptoms of multiple sclerosis (MS), mental health care can be a part of routine MS care through the regular use of screening tools and an integrated approach to treatment, according to a recently published paper. Mood and mental health disorders such as depression, anxiety, adjustment…
Clinical trials and studies, which are essential to the development of new drugs and treatments, need to be conducted under strict ethical, clinical and investigational structures. The most common are investigational trials with new medications or new devices. There are also studies involving outcome measurements and those looking at how people most effectively manage disease….
Clinical research drives progress for every element of health and requires global collaboration. At Norton Healthcare alone, our research teams lead and contribute to studies about pediatric medicine, cancer, infectious diseases, cardiology, neurology, the spine, orthopedics and many other specialties. Research requires meticulous attention to detail and a strong commitment to ethical integrity, not to…
Our goal is to offer every patient the option of the latest treatment available for their cancer. To do that, Norton Cancer Institute is participating in approximately 170 clinical trials at any time. These clinical trials involve nearly 500 patients either enrolled and receiving treatment, or in follow-up. For the participating patients, these studies offer…
A multidisciplinary team of interventional cardiologists and a cardiothoracic surgeon performed Louisville’s first successful transcatheter replacement of a native mitral valve this week. The team with Norton Heart & Vascular Institute Structural Heart Program used a transcatheter aortic valve (commonly referred to as TAVR) to replace the patient’s mitral valve that was unable to be…
Clinical challenge Acute myeloid leukemia (AML) patients ages 75 and older, and younger adults with comorbidities, are often ineligible to receive standard intensive chemotherapy due to high rates of toxicity and early mortality. As a result, supportive care is all that’s available to about 60% of adults 75 or older and younger adults with comorbidities….
Norton Infectious Diseases Institute has been selected by Pfizer as the only site in United States to study how to effectively detect respiratory syncytial virus (RSV) in adults. “For the most part, RSV attention has been focused on children,” said Julio A. Ramirez, M.D., FACP, chief scientific officer, Norton Infectious Diseases Institute. “But some studies…
The Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for Perioperative Spine: Preoperative Osteoporosis Assessment recently was published in Neurosurgery. To develop these recommendations, the authors performed systematic review of the literature using national databases for studies relevant to preoperative diagnostic studies that predict increased risk of osteoporosis-related postoperative complications and whether the preoperative…
New evidence-based guidelines covering five key perioperative spine assessments were issued recently by the Congress of Neurological Surgeons. The guidelines, published in the medical journal Neurosurgery, provide insight on the following: Preoperative osteoporosis assessment Preoperative nutritional assessment Preoperative pulmonary evaluation and optimization Preoperative opioid evaluation Preoperative surgical risk assessment A team of eight physicians from…
A cutting-edge new treatment specifically targets prostate cancer cells to deliver a tumor-killing radioisotope and helped extend patients’ lives longer in an international clinical trial (VISION Study), according to a study published in the New England Journal of Medicine (NEJM) on Sept. 16, 2021. The drug, lutetium-177–PSMA-617, was used to treat patients with metastatic castration-resistant…