Research Archives - Norton Healthcare Provider

Implementing principles of trauma-informed care

Reviewed by Amber L. Pendleton, M.D. Implementing the principles of trauma-informed care across a primary care team and community resources provides an opportunity to focus on adverse childhood experiences and social-care needs, with the potential […]

Essentials of clinical trials

Clinical trials and studies, which are essential to the development of new drugs and treatments, need to be conducted under strict ethical, clinical and investigational structures. The most common are investigational trials with new medications [...]

Study of Paxlovid for children with COVID-19 underway at Norton Children’s Research Institute

Norton Children’s Research Institute, affiliated with the UofL School of Medicine, is involved in a study to evaluate the safety, pharmacokinetics and efficacy of nirmatrelvir/ritonavir (authorized as Paxlovid in older children and adults) in symptomatic [...]

Clinical research: Asking questions, sharing answers

Clinical research drives progress for every element of health and requires global collaboration. At Norton Healthcare alone, our research teams lead and contribute to studies about pediatric medicine, cancer, infectious diseases, cardiology, neurology, the spine, […]

Study shows low-dose cadmium threshold for testicular ferroptosis in mice

Cadmium, a natural element used for rechargeable batteries and other industrial applications, can induce a novel type of testicular cell death in mice after low-dose exposure, according to a groundbreaking study. Cadmium is known to […]

Anti-CD20 monoclonal antibody therapy for relapsing MS in adult patients

Anti-CD20 monoclonal antibody therapy represents a major advance in treating relapsing multiple sclerosis (MS) in adult patients, reducing relapse risk and mitigating disability progression. These monoclonal antibody therapies deplete circulating B cells by targeting CD20, [...]

Reduced-toxicity myeloablative conditioning regimen effective against high-risk pediatric leukemias

A low-toxicity myeloablative conditioning regimen is safe and effective in treating high-risk leukemias, particularly myeloid disease, according to a study recently published in the journal Pediatric Blood & Cancer. Conventional myeloablative conditioning is effective at […]

Offering the latest childhood brain tumor therapies so kids and their families don’t have to travel far from home

Brain tumors are now the leading cause of cancer-related deaths among children. Year after year, Kentucky ranks among states with the highest incidence of children with brain tumors, and Kentucky currently ranks third in the [...]

Insurance-driven inhaler changes have a negative impact on asthma control in children

Children on Medicaid in Kentucky who experience asthma may have had a tougher time managing their symptoms following a payer-initiated formulary change that led to the use of a different inhaler device, according to a […]

Neurocognitive deficits in adult congenital heart disease patients

Individuals with mild-to-moderate adult congenital heart disease (ACHD) had poorer neurocognitive performance, most significantly in tests of alphanumeric trail-making, in a recent study published in the Journal of the American Heart Association. Deficits in alphanumeric […]

Erythrocytapheresis minimizes iron load and improves growth in sickle cell patients

Erythrocytapheresis (automated red cell exchange) increasingly is used to replace sickled red cells in sickle cell disease (SCD) patients as an alternative to transfusion. The procedure doesn’t significantly raise the total hemoglobin — a frequent […]

Category: Research