Failure of endoscopic third ventriculostomy (ETV) to relieve hydrocephalus in patients with midline brain tumors may be an early indication of an underlying histone H3K27M mutation, according to a recently published study.
Researchers at the Norton Healthcare Brain Tumor Center are conducting a clinical trial to determine whether a promising new immunotherapy drug, SurVaxM, improves survivability of glioblastoma. SurVaxM targets survivin, a protein in 95% of glioblastomas and many other cancers. The immunotherapeutic is designed to trigger the patient’s immune system to attack cancer cells with survivin….
The patient A 39-year-old nursing student initially presented with complaints of a two-year history of intermittent numbness in the tips of the middle and ring finger on her left hand. Over the past six months, she developed episodic numbness in the left face and twitching in the left eye. An MRI scan demonstrated a brain…
The patient A 48-year-old woman presented with a history of morbid obesity (376 pounds, BMI 66 kg/m²), hypertension (142/80 on multiple antihypertensive medications), uncontrolled diabetes mellitus (hemoglobin A1C of 9.1), worsening fatigue and increasing facial hair. Cushing’s syndrome is characterized by abnormally elevated levels of cortisol and causes symptoms of obesity, hypertension, hyperglycemia, hirsutism, thin…
After participating in a groundbreaking clinical trial that showed the Optune tumor treatment field device improves glioblastoma multiforme survival when combined with chemotherapy, neuro-oncologists at the Norton Healthcare Brain Tumor Center in Louisville, Kentucky, are treating non-trial participants. Approval by the Food and Drug Administration (FDA) of the device in conjunction with maintenance temozolomide chemotherapy…
The patient A 57-year-old man presented to the Norton Brownsboro Hospital emergency department with complaints of headaches that started two weeks earlier and worsened over the preceding few days. In addition, his family reported subtle changes in behavior, including increased sleepiness and issues with memory. A magnetic resonance imaging (MRI) scan demonstrated a brain mass…