Pediatricians’ primer on childhood CNS tumors

Tumors in the central nervous system (CNS) account for 20% of childhood cancers, with 5.65 cases and 0.72 deaths per 100,000 children under 14 in the United States. Brain tumors are second only to acute […]

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MEK Inhibitor shrinks large hypothalamic enhancing tumor in teen

The patient A 14-year-old female presented with worsening headache and deterioration of vision especially in the left eye. MRI detected a large hypothalamic enhancing tumor causing mass effect on the optic nerves. The pituitary gland […]

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Classification and treatment of pediatric cancerous brain tumor, medulloblastoma

Medulloblastoma is one of the most common malignant brain tumors in children, with cases tending to surface around ages 4 or 5. Currently, the treatment protocol is resection of as much of the tumor as […]

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Diagnosing and treating brain tumors in children

There are many types and subtypes of brain tumors in children, and heterogeneity is common among tumors with similar morphology, according to Mustafa Barbour, M.D., pediatric hematologist/oncologist at Norton Children’s Cancer Institute, affiliated with the [...]

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The acute lymphoblastic leukemia link to obesity

Survivors of the most common childhood cancer, acute lymphoblastic leukemia (ALL), need long-term monitoring for obesity and other ongoing health consequences of their disease and treatment. “The etiology of obesity among ALL survivors is not […]

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Burkitt lymphoma, one of the more common forms of non-Hodgkin lymphoma, has a variety of clinical presentations

Burkitt lymphoma, an aggressive subtype of non-Hodgkin lymphoma (NHL), accounts for 40% of all NHL cases in the United States. This high-grade, fast-growing form of lymphoma starts in the immune system’s B cells and has […]

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Immunotherapy for refractory B-cell acute lymphoblastic leukemia

The five-year survival rate for children and adolescents with acute lymphoblastic leukemia (ALL) has reached about 90% with chemotherapy. Clinicians increasingly are turning to immunotherapy for relapsed/refractory B-cell ALL (B-ALL). Immunotherapy harnesses the innate power [...]

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Don’t overlook these signs and symptoms of leukemia in children

Pediatricians can help with early detection of childhood leukemia during routine visits. Even though a patient’s signs and symptoms may appear vague, mild or suggestive of more common health conditions, they shouldn’t be ignored. In […]

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Reduced-toxicity myeloablative conditioning regimen effective against high-risk pediatric leukemias

A low-toxicity myeloablative conditioning regimen is safe and effective in treating high-risk leukemias, particularly myeloid disease, according to a study recently published in the journal Pediatric Blood & Cancer. Conventional myeloablative conditioning is effective at […]

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Offering the latest childhood brain tumor therapies so kids and their families don’t have to travel far from home

Brain tumors are now the leading cause of cancer-related deaths among children. Year after year, Kentucky ranks among states with the highest incidence of children with brain tumors, and Kentucky currently ranks third in the [...]

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Optimizing leukemia/lymphoma care with a multidisciplinary team

The most effective way to optimize patient care revolves around a combination of physicians, nurses, pharmacists, nurse practitioners, social workers and case managers. Members of the team work together to help with decision-making in each […]

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Access to evolving clinical science close to home

Norton Cancer Institute’s clinical research program was developed to ensure that cancer patients in our community and region have access to evolving clinical science. Guided by an experienced cadre of physicians and supported by a […]

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