In-hospital consumption of opioids after elective spine surgery is driven chiefly by age, previous opioid use, smoking and the number of levels fused, according to a recent study published in the Journal of Spine Surgery. With as many as 38% of patients nationally still on opioids one year after elective spine surgery, the researchers sought…
Patients with advanced/unresectable or metastatic breast cancer treated with palbociclib combination therapy experienced low levels of baseline pain and fatigue, a recent study found. The study is apparently one of the first outside a clinical trial to evaluate the day-to-day effects of advanced/unresectable or metastatic breast cancer and its treatment along with the effects of…
A new study published in Epilepsy Research found 64.3% of patients with various forms of drug-resistant epilepsy in the LAANTERN (Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System) registry were free of disabling seizures, reaching Engel I, after one year. Sixty patients were enrolled in the study specifically for epilepsy treatment. Forty-two reached…
The University of Kentucky, in partnership with Baptist Health Lexington and Norton Healthcare in Louisville, has been selected as a testing site for the Janssen Pharmaceutical Companies of Johnson & Johnson’s Phase 3 clinical research study, called the ENSEMBLE trial, to evaluate Janssen’s investigational COVID-19 vaccine candidate, JNJ-78436735, also known as Ad26.COV2.S. The Phase 3…
A COVID-19 patient at Norton Healthcare is the first in the world to participate in a randomized Phase 2 clinical study using low-dose selinexor. This oral drug, manufactured by Karyopharm Therapeutics Inc. and marketed as XPOVIO, is currently approved at higher doses by the U.S. Food and Drug Administration (FDA) as a treatment for cancer patients with relapsed or refractory multiple myeloma….
The Norton Healthcare pharmacy department has been recognized with a prestigious award for its efforts to speed antibiotics to patients with bacterial infections that have spread to the bloodstream. The American Society of Health System Pharmacists awarded a Best Practices Award to the Norton Healthcare rapid bacteremia response protocol. As part of the Norton Healthcare…
Robert C. G. Martin II, M.D., Ph.D., has published research in Annals of Surgical Oncology, in a paper titled “Evaluating the Regulatory Immunomodulation Effect of Irreversible Electroporation (IRE) in Pancreatic Adenocarcinoma.” Dr. Martin is a surgical oncologist in multidisciplinary collaboration between Norton Cancer Institute and the University of Louisville. This study evaluated an institutional review…
As the clinical program for headache medicine has expanded within Norton Neuroscience Institute and further clinical developments have been made in the field of treating headache disorders, our clinical research department has grown. We have participated in several trials that have ultimately led to the FDA approval of products, as well as products that are…
It’s not unusual for the presence and expertise of Norton Leatherman Spine surgeons to be requested at medical conferences around the world. This year alone, Norton Leatherman Spine physicians served as keynote speakers at spine conferences in Denmark, Spain, Argentina and Japan, where they presented findings from recent studies. “Our team considers these opportunities an…
Nohla Therapeutics initiates Phase 2 LAUNCH clinical trial to assess optimal dosage of innovative cell therapy for those with acute myeloid leukemia. A treatment made from umbilical cord blood is helping oncology and hematology specialists at Norton Cancer Institute reduce infections in patients getting high-dose chemotherapy to treat acute myeloid leukemia (AML). The intensive chemotherapy…
Eran Rosenberg, M.D. and Dennis S. Peppas, M.D. with Norton Children’s Urology recently published a case study on Lesch-Nyhan syndrome, a rare inborn error of pure metabolism marked by a complete deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT). Inherited as an X-linked recessive genetic disorder that primarily affects males, patients with Lesch-Nyhan syndrome exhibit severe…
Norton Healthcare offers a wide range of research opportunities for clinicians and their practice groups, as well as clinicians partnering from other entities. More than 850 studies were active or pending through mid-December 2017. “Norton Healthcare’s research support infrastructure makes a difference in both physician recruitment and retention,” said Stephen W. Wyatt, DMD, MPH, chief…