A groundbreaking clinical trial at Norton Cancer Institute is exploring whether CAR T-cell therapy —a cellular therapy originally developed to treat cancer — could provide a curative treatment for patients with severe autoimmune diseases, including systemic lupus erythematosus (SLE), myositis and scleroderma. The RESOLUTION trial, led by principal investigator Don A. Stevens, M.D., hematologist/oncologist with…
Reviewed by Anupama Raghuram, M.D., and Julio A. Ramirez, M.D. Norton Infectious Diseases Institute researchers are challenging the traditional view of pneumonia as a self- limited acute lung infection, revealing that the disease may be associated with chronic complications affecting multiple organ systems for years after initial diagnosis. Julio A. Ramirez, M.D., and Anupama Raghuram,…
Norton Cancer Institute’s gynecologic oncology research program continues to expand rapidly, helping address a critical regional gap in specialty treatment and clinical research access. Nationally, gynecologic oncology is heavily driven by early phase trials, underscoring the need for programs that advance novel therapies and accelerate progress in treatment options. Our current gynecologic oncology studies include…
Norton Healthcare and Norton Children’s are now contributing vital resources to diabetes research efforts nationwide. As a new member of the Integrated Islet Distribution Program (IIDP), the Norton Islet Cell Research and Transplant Program, housed within Wendy Novak Diabetes Institute, supplied its first round of human pancreatic islet cells to researchers across the country, including…
[vc_row][vc_column][vc_column_text]Norton Children’s Pulmonology, affiliated with the UofL School of Medicine, is actively recruiting adolescent participants who meet criteria for a clinical trial of two inhaled treatments for asthma. According to the Centers for Disease Control and Prevention, more than 6 million children in the United States have asthma. Even with sufficient symptom management, asthma exacerbations…
Failure of endoscopic third ventriculostomy (ETV) to relieve hydrocephalus in patients with midline brain tumors may be an early indication of an underlying histone H3K27M mutation, according to a recently published study.
[vc_row][vc_column][vc_column_text]Cardiac centers around the world are accepting patients for a clinical trial for patients undergoing cardiac surgery that may have risk factors for atrial fibrillation (A-fib) and ischemic stroke.
A recent study published in the The Journal of Prevention of Alzheimer’s Disease provides detailed insight into clinicians’ and patients’ initial experience with lecanemab, the first Food and Drug Administration-approved antiamyloid monoclonal antibody infusion proven to slow cognitive and functional decline due to Alzheimer’s disease. Conducted at the Norton Neuroscience Institute Memory Center, the study…
A world-renowned diabetes researcher has joined Wendy Novak Diabetes Institute, a part of Norton Healthcare and Norton Children’s, with the goal of curing Type 1 diabetes. Balamurugan N. Appakalai, Ph.D., also known as Dr. Bala, is a leading researcher in islet cell transplants and is widely considered one of the most skilled islet isolation specialists…
Clinical research, including clinical trials, is a crucial component to advancing the discovery of cancer therapeutics. Norton Cancer Institute contributes to this advancement through participation in numerous clinical trials every year. 4 phases of clinical trial There are four phases in a clinical trial, each with a different purpose. This helps researchers answer different questions…
An internationally known researcher is joining Wendy Novak Diabetes Institute, a part of Norton Healthcare and Norton Children’s, with the goal of curing Type 1 diabetes. Norton Healthcare and Norton Children’s announced plans to build a specialized laboratory to help him and his team carry out their groundbreaking work and become a hub for diabetes research…
Norton Research Institute will expand research efforts with the unveiling of the new Norton Research Institute Clinical & Translational Research Laboratory. The 7,200-square-foot facility, located inside Norton Healthcare Pavilion in downtown Louisville, will afford ample space and resources for scientists to conduct cutting-edge research, with the goal of producing more meaningful, applicable results directly benefiting patient…