Butyrate-producing gut bacteria are a promising target for preventing and treating memory loss associated with Alzheimer’s disease, according to research presented recently at the Alzheimer’s Association International Conference (AAIC) in Amsterdam, Netherlands. The research in 3XTg mouse model demonstrated that oral administration of tributyrin mitigates age-associated loss of butyrate-producing bacteria and prevents the decline in…
Surgeons face two choices for infants with critical left heart obstruction who have had prior hybrid palliation: a Norwood operation or a comprehensive stage II (COMPSII). The critical left heart obstruction cohort of the multi-institutional Congenital Heart Surgeons’ Society looked at patient characteristics and outcomes for these two pathways. The study, “Norwood Operation Versus Comprehensive…
A human Phase 1 immunotherapy clinical trial is underway using natural killer cells, or NK cells, to target relapsed or refractory acute myeloid leukemia. Acute myeloid leukemia patients who have exhausted other treatment options are potential candidates for the trial, ClinicalTrials.gov ID NCT05470140. The trial uses cytokine-reprogrammed, non-engineered, “off-the-shelf” NK cells from a healthy donor….
Rachel L. Evans, M.D. Pediatric Neurology Stephanie M. Green, D.O. Pediatric Physical Medicine and Rehabilitation Kelly A. Jenkins, M.D. Pediatric Orthopedic Surgery Michael S. Orangias, M.D. Pediatric Pulmonology, Pediatric Sleep Medicine Huma N. Rasheed, M.D. Pediatric Cardiology Zachery T. Sensing, M.D. Hospital Medicine Jennifer Smith, M.D. Pediatric Hospital Medicine Frederick J. Stocker…
Jonathan P. Boland, M.D. Emergency Medicine James C. Gray IV, M.D. Emergency Medicine Stephanie Miles, M.D. Family Medicine Vladimir Pulgaron, M.D. Family Medicine Steven J. Radtke, M.D. Urogynecology Cindy Truong, D.O. Internal Medicine Michael McCool II, PA-C Neurosurgery Alexandria J. Bassler, APRN Thoracic Surgery Tracy C. Jensen, APRN Internal Medicine Whitney L. King, APRN Cardiology…
The 28th Gail Klein Garlove Lectureship on Nov. 1 is titled “Advancing Precision Medicine Through New Discoveries and Technologies,” and will be presented by Sameek Roychowdhury, M.D., Ph.D., medical director of the cancer genomics laboratory and medical oncologist at The Ohio State University Comprehensive Cancer Center – James. The event is hosted by Norton Healthcare…
At some point in their life, 1 in 8 women will develop breast cancer. Approximately 20% of breast cancer cases are familial, affecting two or more women in the same family, usually at a later age. An estimated 5% to 10% of breast cancers are caused by a genetic mutation, called hereditary breast cancer. Red…
A local icon in the pediatric world has passed away. Richard S. “Dick” Wolf, M.D., who served as medical director of Norton Children’s Hospital from 1983 through 1995, passed away Oct. 17, 2023. In addition to being a well-known local pediatrician for 30 years, Dr. Wolf was instrumental in building Norton Children’s Hospital into what…
Patients often suspect a thyroid condition is responsible for their weight gain or their weight loss struggles. Much of the stimulus for this belief is based on the internet, according to Lisal J. Folsom, M.D., M.S., a pediatric and adult endocrinologist with Norton Community Medical Associates and Norton Children’s Endocrinology, affiliated with the UofL School…
Primary care and sports medicine providers hear frequently from patients about hip and knee pain, especially among older adults. The threshold for referral to an orthopedic specialist for possible joint replacement focuses on pain and disability. Most hip and knee replacements are done between ages 50 and 80, but hip and knee replacements have been…
The patient A 4-year-old girl presented with congenital heart disease consisting of partial atrioventricular canal defect. Surgical repair was necessary. The challenge Injury to the cardiac conduction system during cardiac surgery may result in complete heart block in 25% of patients with the most complex congenital heart defects. The injury interrupts the electrical signals transmitted from…
Stephanie A. Merimee, M.D., an orthopedic surgeon, has joined the team at Norton Louisville Arm & Hand. Dr. Merimee has a medical degree from the University of Louisville School of Medicine. She completed her residency at the University of South Florida and Florida Orthopaedic Institute in Tampa, Florida. Prior to coming back to Louisville, Dr….